30 aprile

Istituto Europeo di Oncologia, Via Ripamonti, 435 Milano - Room Direzione Scientifica
13:00Board meeting of the steering committee
Plenary Session
14:00Registration
15:30Opening ceremonyChairmen N. Mozzillo,
A. Testori
and J. Gershenwald
16:00Welcome messageM. Melis
G. Ciliberto
S. Lodato
R. Orecchia
16:30A tribute to Donald MortonM. Faries
16:40A tribute to Natale CascinelliA. Testori
16:50A life dedicated to conservative surgeryU. Veronesi
17:00AJCC melanoma staging system: towards a 8th editionJ. Gershenwalds
17:10Break

SNB: future prospects
ChairmenC.M. Balch
P. Delrio
17:20MelanomaN. Mozzillo
17:30BreastH. Cody III
17:40Head & NeckR. Martin
17:50Gastro intestinalY. Kitagawa
18:00ColorectalS. Saha
18:10Urology H.G. van Der Poel
18:20GynecologyS. Greggi
18:30The role of sentinel node in the future of cancer managmentC.M. Balch
18:45Assembly ReportJ. Gershenwald
19:20Cocktail dinner (transfer by bus to Testori’s family country house)

1 maggio

Nhow Hotel, Via Tortona 35, Milano
Sentinel Node and Technologies
ChairmenS. Lastoria
S. Vidal Sicar
08:30Overview of LymphoscintigraphyR. Uren
08:45Enhanced receptor-targeting with Tilmanocept for lymphatic mappingA. Wallace
09:00Hybrid tracers for combined radioactivity/fluorescence detectionF. van Leeuwen
09:15Indocyanine Green for Fluorescence Imaging K. Joachim
09:30SPECT/CT for preoperative sentinel lymph node localization in areas of complex anatomyR. Valdés Olmos
09:45Sestamibi-guided biopsy of radiologically occult breast lesions using dedicated gamma camera devicesL. Pereira Arias
10:00Sentinel node biopsy in early stage breast cancer with a single incision and no lymphoscintigraphyM. Rizzo
10:15Fluorescent identification of sentinel node in the invisible light rangeR. Andtbacka
10:30Discussion
10:45Break
Sentinel Node Biopsy pathologists session towards a consensus on SN sectioning
ChairmenA. Cochran
G. Viale
11:00The EORTC sectioning protocolS. Koljenovic
11:15The UCLA sectioning protocolA. Cochran
11:30The Australian Sectioning ProtocolL. Jackett
11:45ITC Identification and biological
significance in breast
A. Sapino
12:00Augsburg/Rotterdam classification of Melanoma SLN metastases and its prognostic valueH. Starz
12:15Are SN data bases comparable?A. Van Akkooi
12:30Intraoperative frozen sectioning in breast
and melanoma
PRO & CON
A. Spatz
12:45SLN status and computational image analysisR. Riber-Hansen
13:00Discussion
13:15Lecture: Follow up randomized study on melanoma: updateA. Testori
13:30Lunch
13:45 - 14:45Satellite symposium by Ithera medical

Microstaging and clinical decisions
ChairmenR. Andtbacka
D. Massi
14:45Histophatology of positive SNB and long term outcomeA. Cochran
15:00Clinical role of ITC in SLNC. R. Rossi
15:15Cancer metastasis from tumor microenvironment to the sentinel lymph nodeS. Leong
15:30Correlation between sentinel node status
and mutational profile in melanoma
G. Botti
15:45Confocal microscopy may help to select
thin melanoma patients for SNB?
G. Pellacani
16:00Is completion LND indicated?PRO M. Ross
CON D. Coit
16:30Discussion
16:45Break

Sentinel Node Biopsy melanoma session
ChairmenN. Mozzillo
A. Testori
17:00The role of sentinel node staging in the design and end results reporting of cancer clinical trialJ. Thompson
17:15SLN for atypical melanocytic neoplasmsM. Yamamoto
17:30Is there a good timing for SLN biopsy?A. Tejera-Vaquerizo
17:45Management of patients with positive nodes on an ectopic location of the sentinel node (epitrochlear, popliteal, trunk)C. Caracò
18:00Role of guided FNA in diagnosis and prognosisO. Catalano
18:15From open to minimally invasive lymphadenectomy: learning curve and results in quality of lifeJ. Soteldo
18:30Discussion
18:45Closure
08:00 - 09:00 Abstract presentations and new studies proposed
08:00 - 09:00Melanoma
ChairmenE. Pennacchioli, G. Di Monta
1.Is there a single or rare there multiple sentinel lymph nodes for melanoma?
DM Balkin, F.Wang, EM. Balkin, C O’Donoghue, M Kashani Sabet, JS Zager, SP Leong
2.A portable hybrid camera for fused optical and scintigraphic imaging: clinical experience in melanoma patients
S Vidal Sicart, A Bennássar, A Tapias, P Perlaza, N Sánchez, A Seva
3.Lymph nodes’ capsular naevi are associated with high naevus count in melanoma patients: a case control study
S Ribeiro, C Longo, F Specchio, G Argenziano
4.Different measurement of microscopic tumor burden and its prognostic role in sentinel lymph node in patients with cutaneous melanoma
G. Di Monta, U. Marone, ML. Di Cecilia, C. Caracò
5.The use of a portable gamma camera for the intraoperative detection of additional sentinel nodes in melanoma patients
SP Leong, M Wu, Y Lu, D Torre, MA Garrett, M Heller Benson, A Wight, C Ospina, W Luckett, M Kashani Sabet
6.When to perform a sentinel lymph node biopsy in thin melanoma?
E Gironés, LL Pascual, AC Iturriagagoitia, C E Estébanez
7.Report of the use of Tc 99m for SLNB in skin melanoma patients at Surgical Oncology Clinic, NCRC of Serbia, Belgrade, years 2013 2014 2015
A Martinovic, N Santrac, M Buta, M Kocic, A Koljević Markovic, S Tasic, R Dzodic
8.Quantification of melanoma spread in the sentinel node and survival
U. Anja, K. Dietz, I. Hodak, B. Polzer, S. Scheitler, M. Yildiz, C. Zbigniew, P. Lehnert, T. Fehm, C. Hafner, S. Schanz, M. Rochen, C. Garbe, H.Breuninger, G. Fierlbeck, C. Klein

Sentinel Node in lung cancer
ChairmenG. Rocco
L. Santambrogio
14:45Update on indications and study resultsY. Colson
15:00Technical devices and new methods to detect SNG. Rocco
15:15Staging pathways: SNB or imagingPRO Y. Colson
CON L. Spaggiari
15:30Update on new therapies on advanced lung cancerL.Buffoni
15:45Discussion
16:00Break

16:10 - 18:30 Abstract presentations and new studies proposed
ChairmenP. Delrio, M. Ansarin
13:10The treatment of peripheral advanced secondary lymphedema. While the early bird catches the worm, the late riser still benefitsC. C. Campisi
16:30 - 17:30Gastrointestinal, Urology, Head & Neck
1.The Clinical usefulness of the intraoperative detection of sentinel lymph note metastases by a rapid RT PCR system in patients with gastric cancer
M Khalid, S Yanagita, Y Uenosono, T Arigami, K Okubo, T Kijima, M
Amatatsu, S Natsugoe
2.The application of ICG fluorescence sentinel node biopsy for early gastric cancer to the laparoscopic function preserving gastrectomy
S Kinami, T Oonishi, Y Fujii, J Fujita, D Kaida, Y Tomita, H Fujita, Y Nakano,
N Ueda, T Kosaka
3.The sentinel lymph node procedure with isosulfan blue or fluorescence imaging shows comparable upstaging rates in patients with node negative colon cancer – A prospective comparative study
B Weixler, A Rickenbacher, DA Raptis, M Zuber
4.Non exposed endoscopic wall inversion surgery with sentinel node basin dissection for early gastric cancer
A Shimada, H Takeuchi, O Goto, K Fukuda, R Nakamura, T Takahashi, N Wada, H Kawakubo, T Nakahara, K Murakami, M Jinzaki, N Yahagi, Y Kitagawa
5.CLEAN NET with Sentinel Node Dissection for Early Gastric Cancer
Y Uenosono, T Arigami, K Okubo, S Natsugoe
6.Magnetic resonance sentinel lymph node imaging in prostate cancer using intraprostatic injection of superparamagnetic iron oxide nanoparticles
A Winter, T Kowald, TS Paulo, P Goos, S Engels, H Gerullis, A Chavan, F Wawroschek
7.Sentinel Node in Oral Cancer: The Nuclear Medicine Aspects of Sentinel European Node Trial (SENT).
G Tartaglione & Sent Group
8.Sentinel node biopsy technique in gastrointestinal tract cancer
E. Mazza, P Chiaro, M Bellò, P Cassoni, M. Morino, S. Sandrucci, M. Mistrangelo
9.Role of hybrid tracer for sentinel lymph node detection in cervical and endometrial cancer
P. Paredes, S. Vidal-Sicart, A. Tapias, F. Campos, L. Carballo, P. Fusté, S. Martínez-Román, F. Pons, J. Ordi, J. Pahisa, F. Carmona, F. Lomeña
17:30 - 18:30
ChairmenF. Di Filippo, R. Andtbacka
1.Intradermal Stress Lymphoscintigraphy for Screening and Early Detection of Breast Cancer Related Lymphedema
G Tartaglione, R Bartoletti, G Visconti, M Salgarello
2.Improved lymphatic mapping for repeat sentinel node biopsy in ipsilateral breast cancer relapse using SPECT/CT
P Borrelli, ML Donswijk, MP Stokkel, RA Valdés Olmos
3.Innovating radioguided surgery: sentinel node localization in patients with breast cancer using a freehand SPECT mobile gammas camera combination
T Engelen, BMF Winkel, DDD Rietbergen, GH KleinJan, S Vidal Sicart, RA Valdes Olmos, NS van den Berg, FWB van Leeuwen
4.The predictive value of methylene blue dye as a single technique in breast cancer sentinel node biopsy. A study from Dharmais Cancer Hospital
B Brahma, RI Putri, RB Andinata, L Sari, SJ Haryono
5.Feasibility of Sentinel Lymph Node Biopsy after Ipsilateral Breast Tumor Recurrence
Akiko Matsumoto, HiromitsuJinno, Maiko Takahashi, TetsuHayashida, Yuko Kitagawa
6.PET-CT scan vs Sentinel Node Biopsy in the detection of inguinal lymph-node metastases in patients affected by anal cancer
E. Mazza, A. Lesca, M. Bellò, P. Cassoni, U. Ricardi, P. Franco, P. Racca, L. Fanchini, M. Baccega, P. Chiaro, M. Morino, M. Mistrangelo
7.Sentinel Node Biopsy for anal carcinoma
E. Mazza, A. Lesca, M. Bellò, P. Cassoni, U. Ricardi, P. Franco, P. Racca, L. Fanchini, P. Chiaro, M. Baccega, M. Morino, M. Mistrangelo
8.The role of Pet-Ct Scan in the detection of inguinal metastases in patients affected by anal cancer: a review of the literature and a comparison with Sentinel nNode Biopsy and fine needle aspiration
E. Mazza, A. Lesca, M. Bellò, P. Cassoni, U. Ricard, P.Franco, P. Racca, L. Fanchini, M.Baccega, M. Morino, M. Mistrangelo
18:30Closure

2 maggio

What after positive sentinel node
ChairmenF. Di Filippo
O.E. Nieweg
08:30Value of staging imaging in melanoma patients with positive sentinel lymph nodesO. E. Nieweg
08:45Completion lymphadenectomy after positive SLN biopsy MelanomaM. Faries
09:00BreastF. Di Filippo
09:15Oral CavityF. Ionna
09:30Axillary management after neo adjuvant therapy in breast cancerH. Cody III
09:45Discussion
10:00Break
ChairmenA. Costa
D. D’Ugo
10:15Adjuvant therapies of SLN + patients: BreastPRO E. Munzone
CON M. De Laurentiis
10:45Adjuvant therapies of SLN + patients: MelanomaPRO V. Chiarion Sileni
CON S. Mocellin
11:15Update on immunotherapies in adjuvant and advanced melanomaP. Ascierto
11:30Update on target therapy in adjuvant and advanced melanomaP. Queirolo
11:45Video assisted lymphadenectomyA. Sommariva
12:00Break

Recurrence and SNB
ChairmenJ. Gershenwald
S. Zurrida
12:15Follow up for morbidity and recurrenceP. G. Gill
12:30Monitoring sentinel lymph node for circulating tumor cells (CTC) and cell-free circulating DNA/microRNA in melanoma patientsD. Hoon
12:45SNB after melanoma metastasesM. Faries
13:00SNB after breast recurrenceM. Intra
13:15Discussion
13:30Lunch

Sentinel node in Breast cancer
ChairmenF. di Filippo
P. Veronesi
14:30Dedicated PET devices for breast cancer imaging and biopsyPM. Herranz
14:45Sentinel Node Biopsy: still as a standard treatment in breast cancer surgery?H. Cody III
15:00The role of SNB after neo adjuvant therapiesV. Galimberti
15:15Technical devices and new methods to detect SNB. Ballardini
15:30State of the art of SN histological evaluation: still multisection analysis?L. Jackett
15:45Molecular biology on primary and SNB to indicate adjuvant therapiesA. Spatz
16:00Breast imaging: what's new, what is lastA. Gallipoli
M. Mattace-raso
16:15Towards a new era on the role of SNB in breast cancer: ongoing studies reportO. Gentilini
16:30Discussion
16:45Break

Sentinel node in H&N cancer
ChairmanL. Calabrese
A. Pastore
17:00Update on indications and study resultsF. Ionna
17:15Molecular patterns detectable from primary disease and SNBA. Anichini
17:30Staging pathways: SNB or imagingS. Lastoria
17:45Indications for medical therapy in a multisciplinary settingL. Locati
18:00Discussion
18:15Closure
08:00 - 09:00 Abstract presentations and new studies proposed
08:00 - 09:00Melanoma
ChairmenE. Pennacchioli, G. Di Monta
1.Is there a single or rare there multiple sentinel lymph nodes for melanoma?
DM Balkin, F.Wang, EM. Balkin, C O’Donoghue, M Kashani Sabet, JS Zager, SP Leong
2.A portable hybrid camera for fused optical and scintigraphic imaging: clinical experience in melanoma patients
S Vidal Sicart, A Bennássar, A Tapias, P Perlaza, N Sánchez, A Seva
3.Lymph nodes’ capsular naevi are associated with high naevus count in melanoma patients: a case control study
S Ribeiro, C Longo, F Specchio, G Argenziano
4.Different measurement of microscopic tumor burden and its prognostic role in sentinel lymph node in patients with cutaneous melanoma
G. Di Monta, U. Marone, ML. Di Cecilia, C. Caracò
5.The use of a portable gamma camera for the intraoperative detection of additional sentinel nodes in melanoma patients
SP Leong, M Wu, Y Lu, D Torre, MA Garrett, M Heller Benson, A Wight, C Ospina, W Luckett, M Kashani Sabet
6.When to perform a sentinel lymph node biopsy in thin melanoma?
E Gironés, LL Pascual, AC Iturriagagoitia, C E Estébanez
7.Report of the use of Tc 99m for SLNB in skin melanoma patients at Surgical Oncology Clinic, NCRC of Serbia, Belgrade, years 2013 2014 2015
A Martinovic, N Santrac, M Buta, M Kocic, A Koljević Markovic, S Tasic, R Dzodic
8.Quantification of melanoma spread in the sentinel node and survival
U. Anja, K. Dietz, I. Hodak, B. Polzer, S. Scheitler, M. Yildiz, C. Zbigniew, P. Lehnert, T. Fehm, C. Hafner, S. Schanz, M. Rochen, C. Garbe, H.Breuninger, G. Fierlbeck, C. Klein

Lymphoedema Following SLN biopsy and TLND
ChairmenC. Campisi
L. Borgognoni
09:00Pre and post-operative evaluation of patients at risk of lymphedemaM. Pinto
09:15Diagnosis, staging and conservative treatment of Lymphoedema following SNB or TLNDS. Leong
09:30Reverse Lymphatic mappingS. Klimberg
09:45Lymphovascular anastomosisF. Boccardo
10:00Randomized study proposal to prevent lymphedema on groin-axillaryF. De Cian
10:15Lymph node transplantationJ. H. Dayan
10:30Discussion
10:45Break

Sentinel node in abdominal cancer
ChairmenF. Corcione
Y. Kitagawa
11:00Technical devices and new methodsF. Corcione
11:15Update on indications and results in upper G.I.H. Takeuchi
11:30Update on indications and results in colonS. Saha
11:45Molecolar patterns detectable from primary disease, metastatic lesions and liquid biopsiesA. Bardelli
12:15Staging pathways on laparoscopic and robotic approachPRO P. Bianchi
CON U. Fumagalli
12:30Indications for medical therapyA. Avallone
13:00Discussion

13:15 Lunch and abstract presentation
13:15 - 14:15Melanoma
ChairmenC. Caracò, P. Queirolo
1.Sentinel lymph node mapping using a blue dye as only method tertiary medical center experience
D Nikolic, M Granic, M Djorjdevic, A Nikolic
2.A 17 year retrospective audit of outcome in patients undergoing sentinel lymph node biopsy in thin melanoma
Elena Goni Girones, Jose Rey Vasalo, Juan Ignacio Yanguas Bayona, Carmen Estabanez Estebanez
3.Combined analysis of Phase III trials evaluating (99mTc) Tilmanocept and vital blue dye for identification of sentinel lymph nodes in clinically node negative cutaneous melanoma
VK Sondak, DW King, JS Zager, S Schneebaum, J Kim, SPL Leong, MB Faries, BJ Averbook, SR Martinez, CA Pulco, JL Messina, L Christman, AM Wallace
4.Gamma probe and Ultrasound Guided Fine Needle Aspiration Cytology of the Sentinel Node in Melanoma and Breast Cancer
Patients.
First Results Pilot GULF Trial.
C.M.C. Oude Ophuis, L.B. Koppert, C. de Monyé, S. Koljenović, C.H.M. van Deurzen, C. Verhoef, D.J. Grünhagen
5.Fdg pet/ct imaging as a diagnostic tool for progression evaluation of melanoma. Is it really so precise? Case report
Dejan Nikolic, Zlatko Skuric, Violeta Stanimirovic, Aleksandra Nikolic
6.Lymphoseek: a molecular imaging agent for melanoma sentinel lymph node mapping
AM Wallace, CK Hoh, SJ Ellner, DD Darrah, G Schulteis, DR Vera
7.Routine PET/CT and Brain MRI at the time of diagnosis in patients with regional metastatic melanoma rarely identifies systemic disease
EP Miranda, B Jaron, M Kashani Sabet, SPL Leong
8.Prospective study on the value of repeat lymphoscintigraphy on the detection of node status in patients undergoing lymph nodal complete radical dissections for melanoma: pilot study and full protocol
A Testori, CR Rossi, G Mazzarol, F Verrecchia, S Gandini, F Cataldo

Sentinel node in gynecologic neoplasms
ChairmenS. Greggi
M. Thill
14:30Update on indications and study resultsA. van Der Zee
14:45Technical devices and new methods to detect SN (Paramagnetic particles)M. Thill
15:00Molecular patterns detectable from primary disease and SNBG. Palmieri
15:15Staging pathways: SNB or imagingPRO N. Abu Rustum
CON V. Zanagnolo
15:45Indications for medical therapy in a multidisciplinary settingN. Colombo
16:00Discussion
16:15Break
Sentinel node in prostate cancer
ChairmenS. Perdonà
G. Renne
F. Wawroschek
16:30Update on indications and study resultsF. Wawroschek
16:45Technical devices and new methods to detect SNH. G. van Der Poel
17:00Atypical lymph node metastatic sites and SLNBR. Montironi
17:15Robotic surgery on prostate cancer+/-SNBO. De Cobelli
17:30Update on immunotherapies on advanced urological cancerA. Pignata
17:45Discussion
18:00Closure